The U.S. Department of Energy National Virtual Biotechnology Laboratory (NVBL) is a consortium of DOE National laboratories, each with core capabilities relevant to the threats posed by COVID-19. The NVBL is taking advantage of DOE user facilities, including light and neutron sources, nanoscale science centers, sequencing and bio-characterization facilities, and high performance computer facilities, to address key challenges in responding to the COVID-19 threat.  Examples include developing innovations in testing capabilities, identifying new targets for medical therapeutics, providing epidemiological and logistical support, and addressing supply chain bottlenecks by harnessing extensive additive manufacturing capabilities.  The NVBL collaborates extensively with researchers, both in academia and the private sector.  In addition, the DOE user facilities are available to users in all sectors of the research community.