The Department of Energy (DOE) Isotope R&D and Production Program (IP), managed by the Office of Science, leverages eight national laboratories and three universities to provide the Nation with critical isotopes in scientific, medical, security, and industrial applications. These institutions represent a globally unique capability coordinated by the DOE IP to produce and distribute radioactive and stable isotopes that are a key facet of ensuring Nation’s security and prosperity. The sale and distribution of isotopes is coordinated through the National Isotope Development Center (NIDC), which is managed by the DOE IP. A robust portfolio of cutting-edge R&D activities at these and many other institutions that continues to push the boundaries of isotope production and enable new applications of radioactive and stable isotopes is also stewarded by the DOE IP.